Rifampin (Rifadin®, Rimactane®) is used in the treatment of leprosy, Nocardia mycetoma, and other infections with sensitive organisms.
Jaundice - rifampin can produce liver dysfunction and increase pre-existing liver damage.
- Pregnancy - while it has been used in pregnancy successfully, rifampin may be teratogenic at high dosage.
- Pregnancy - post partum hemorrhage in mother and infant can occur, and both should receive vitamin K.
- Ketoconazole reduces the efficacy of rifampin, and vice versa.
- Patients should be warned that their urine will be a reddish orange.
- Transient elevation of liver enzymes, and rarely, jaundice.
- Rifampin is used in combination with other systemic medications for the treatment of leprosy.
- Standard dosage is 600 mg monthly for 6 months or more.
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