Prednisone is used orally for a multitude of inflammatory disorders.
For specific dose recommendations: See the specific disease discussion.


  • Systemic fungal infection.
  • Relative contraindication:
  • Active mycobacterial infection, with the exception of reactional states in patients with leprosy on active anti-leprosy therapy.


  • Prednisone can mask evidence of serious bacterial infection, particularly with long term therapy of more than 50 mg daily.
  • Any febrile episode should be cause for the assessment of possible septicemia.

Adverse effects:

  • Cushingoid changes
  • Steroid myopathy
  • Psychosis
  • Exacerbation of GI ulcer
  • Exacerbation of hypertension
  • Pseudotumor cerebri
  • Many others, please consult your compendium.


  • Please consult the specific disease discussion.

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